Background: Debates over legalisation of physician-assisted suicide or euthanasia often warn of a “slippery slope”, predicting abuse of people in vulnerable groups. To assess this concern, the authors examined data from Oregon and the Netherlands, the two principal jurisdictions in which physician-assisted dying is legal and data have been collected over a substantial period.Methods: The data from Oregon comprised all annual and cumulative Department of Human Services reports 1998–2006 and three independent studies; the data from the Netherlands comprised all four (...) government-commissioned nationwide studies of end-of-life decision making and specialised studies. Evidence of any disproportionate impact on 10 groups of potentially vulnerable patients was sought.Results: Rates of assisted dying in Oregon and in the Netherlands showed no evidence of heightened risk for the elderly, women, the uninsured , people with low educational status, the poor, the physically disabled or chronically ill, minors, people with psychiatric illnesses including depression, or racial or ethnic minorities, compared with background populations. The only group with a heightened risk was people with AIDS. While extralegal cases were not the focus of this study, none have been uncovered in Oregon; among extralegal cases in the Netherlands, there was no evidence of higher rates in vulnerable groups.Conclusions: Where assisted dying is already legal, there is no current evidence for the claim that legalised PAS or euthanasia will have disproportionate impact on patients in vulnerable groups. Those who received physician-assisted dying in the jurisdictions studied appeared to enjoy comparative social, economic, educational, professional and other privileges. (shrink)

IntroductionBisphenol A is highly debated and studied in relation to a variety of health outcomes. This large variation in the literature makes BPA a topic that is prone to selective use of literature, in order to underpin one’s own findings and opinion. Over time, selective use of literature, by means of citations, can lead to a skewed knowledge development and a biased scientific consensus. In this study, we assess which factors drive citation and whether this results in the overrepresentation of (...) harmful health effects of BPA.MethodsA citation network analysis was performed to test various determinants of citation. A systematic search identified all relevant publications on the human health effect of BPA. Data were extracted on potential determinants of selective citation, such as study outcome, study design, sample size, journal impact factor, authority of the author, self-citation, and funding source. We applied random effect logistic regression to assess whether these determinants influence the likelihood of citation.ResultsOne hundred sixty-nine publications on BPA were identified, with 12,432 potential citation pathways of which 808 citations occurred. The network consisted of 63 cross-sectional studies, 34 cohort studies, 29 case-control studies, 35 narrative reviews, and 8 systematic reviews. Positive studies have a 1.5 times greater chance of being cited compared to negative studies. Additionally, the authority of the author and self-citation are consistently found to be positively associated with the likelihood of being cited. Overall, the network seems to be highly influenced by two highly cited publications, whereas 60 out of 169 publications received no citations.ConclusionIn the literature on BPA, citation is mostly driven by positive study outcome and author-related factors, such as high authority within the network. Interpreting the impact of these factors and the big influence of a few highly cited publications, it can be questioned to which extent the knowledge development in human literature on BPA is actually evidence-based. (shrink)

The relation of the conformal group to various earlier proposed relativistic quantum mechanical dynamical groups (and other related groups) is studied in the framework of projective geometry, by explicitly constructing the contractions of the six-dimensional coordinate transformations. Five-dimensional realizations are then derived. An attempt is made to improve our physical insight through geometry.

Coastal ecosystems are increasingly dominated by humans. Consequently, the human dimensions of sustainability science have become an integral part of emerging coastal governance and management practices. But if we are to avoid the harsh lessons of land management, coastal decision makers must recognize that humans are one of the more coastally dependent species in the biosphere. Management responses must therefore confront both the temporal urgency and the very real compromises and sacrifices that will be necessary to achieve a sustainable coastal (...) ecosystem, one that is economically feasible, socially just, and ecologically sound. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

This volume is a collection of testimonia and fragments of the Presocratics designed to introduce the Italian high school student to an understanding of what philosophy is. This purpose is so praiseworthy that it should deter the specialist from raising his eyebrows at the volume's shortcomings. Curi has selected only fragments of Thales, Anaximander, Anaximenes, Pythagoras, Xenophanes, and the Eleatics. Empedocles, Anaxagoras and the Atomists are excluded from the selections, presumably because the editor holds, with many Italian scholars, the questionable (...) theory that by "Presocratics" is understood only those thinkers who lived before the birth of Socrates. The translation of texts from the sixth edition of Diels and Kranz is accurate and readable, and the selections of testimonia are more comprehensive than the ones found in the textbooks of Burnet, Nahm, and Robinson. It is pedagogically interesting to ask what the very young may learn from this volume. The answer lies in its short introduction and in the critical footnotes attached to each fragment. Unlike the aforementioned English and American authors, Curi avoids textual exegesis and analysis of the mythopoeic background of Homer and Hesiod to which the early philosophic views may be related. He centers his own comments on the intricate issues of ancient and modern historiography. He analyzes the history of ancient historiography from Aristotle to Mondolfo and concludes that Wilamowitz, Stenzel, and Jaeger are the only historiographers who have been able to capture the complexity of Presocratic philosophy. Curi's method of teaching philosophy and his own philosophical views goes beyond the scope of this notice, however we can not help but remark how much Croce's spirit still pervades the Italian class-room.--L. M. P. (shrink)

Three major problems continue to perplex every interpreter of Stoic logic since Lukasiewicz's [[sic]] revolutionary studies in 1932: the alleged opposition of Stoic dialectic to Aristotelian syllogistic; the baffling status of "implication" in Diodorus and Chrysippus; the questionable completeness of the Stoic system based on the five "indemonstrables." Expanding on Lukasiewicz's [[sic]] findings, Benson Mates and Mary Kneale argued for interpreting Stoic logic in terms of a logic propositions formally analogous to our propositional calculus. Furthermore Mates and, to a less (...) extent, Kneale cast doubts on the accepted opinion that Diodorus' "implication" was the ancient version of what C. I. Lewis calls "strict implication," and opted for B. Russell's "formal implication," while attributing the first type of implication to Chrysippus alone. Finally Mates, Kneale, and Reymond questioned the alleged completeness of the Stoic logic system. Among recent logicians this very question still calls for an answer. In form and content, Mignucci's knowledgeable study on the meaning of Stoic logic is a lucid restatement of his predecessors published conclusions. With the exception of the first chapter devoted to a résumé of the main contributions in the field, the remaining sections of his essay are organized around Mates' topical structure of Stoic epistemology and semantics, the doctrine of the proposition, and the theory of the five "anapodictics." Mignucci makes, however, two relevant additions which may raise suspicion among the most rigorous of logicians. In the first chapter and again in the conclusion of his essay, he analyzes carefully the alleged opposition of Aristotle's logic of classes to the Stoic logic of propositions. For Mignucci, the acceptance of the logic of propositions implies one's commitment to an ontological domain which is incompatible with the metaphysical discourse of the logic of classes. He argues that the two logics are complete and formally analogous only in the sense that from the Stoic first axiom and from the Aristotelian Barbara one can deduce all the rules which constitute their respective logics. This completeness is, however, logically dependent upon the Aristotelian and Stoic view of reality.--L. M. P. (shrink)

John Dewey is one of the American philosophers strongly influenced by Hegel. For this reason, perhaps, certain Italian scholars have always been attracted to him, even when, as in the case of Croce, they strove to repudiate his doctrines. In this tradition, Aloysio's volume blazes the trail for a new approach to Dewey's scholarship in Italy. The volume issues from a seminar held at the University of Aquila during which Aloysio and his students read five works of Dewey. Significantly enough, (...) the works chosen for such an enterprise belong to the period when Dewey bids farewell to the idealism of his youth and takes a critical look at his philosophical program of reconstruction. The chapters of the book are devoted to a critical analysis of the five books studied during the seminar: Reconstruction in Philosophy ; Human Nature and Conduct ; Experience and Nature ; The Quest for Certainty ; and, A Common Faith. The outcome is a refreshing exposition of Dewey's mature thought. The method of question and answer used throughout the book is exceptionally efficacious to evince the contemporary relevance of Dewey's fundamental notions of experience, nature, and human conduct.--L. M. P. (shrink)

The author has succeeded in producing a volume which will be valuable to anyone who wishes to acquire a more catholic view of British analytic philosophy than the one offered in the works of Urmson, Warnock, and Ayer. The bibliography contains 698 items, and each of the ten chapters is amply footnoted with suggestions for further investigations. In the first chapter, Riverso meets the charge of antihistoricism by arguing convincingly that twentieth century analysis is the culmination of a movement which (...) began with Descartes' Regulae ad directionem ingenii. In the following three chapters he considers the entire Cambridge movement from its origin in B. Russell's and G. E. Moore's refutation of idealism to the disintegration of logical atomism in the second Wittgenstein. Italian readers will find especially useful Riverso's clear discussion of the impact of Wittgenstein's Tractatus on the Vienna circle, of his analysis of Ayer's radical refutation of metaphysics, as well as of the polemics of Lazerowitz and Malcolm against the principle of verifiability. In the final four chapters, Riverso takes on the arduous task of telling the story of the whole Oxonian movement. He clarifies beautifully the reasons for the transformation from normal analysis to ordinary language, and finally to the various types of grammatical elucidations of Ryle, Austin, and Strawson. Riverso dedicates a chapter each to the language of perception, the concept of person, religious language, and metaethics. In the concluding pages, he launches into passionate defense of analysis as the best therapy for our social ills and as the only alternative to Marxist ideology.--L. M. P. (shrink)

The preoccupation evinced by Italian scholars for Protagoras and the Sophistic movement is extraordinary and somewhat comparable to the interest which American philosophers have recently shown in Parmenides and the Eleatics. Since the Protagoras revival in the 'Forties' numerous Italian editions of the Sophistic fragments have been published and a constellation of contradictory reconstructions of Protagoras' thought has been offered to a perhaps unduly tolerant public. In the present study Zeppi intends to refute all extant historiography from Gomperz to Capizzi (...) in the name of a unitary interpretation based upon the internal consistency of Protagoras' ethical and epistemological doctrines. Such an interpretation will do justice, Zeppi believes, to the complexity of Protagoras' thinking while revealing the central position he occupies in the philosophical tradition before Plato. Accordingly Zeppi devotes the first part of his essay to Protagoras' doctrines and the second to earlier Presocratics and the Sophists in general. Finally he offers thought-provoking studies on the Anonymus Iamblichi, on the Cyrenaic school, on Democritus' ethics and on its bearing on Protagoras. On the whole Zeppi is more convincing in demolishing the views of his predecessors than in presenting his own ideas. Nevertheless his hypothesis of Protagoras as an ethical emotivist, a sense-datum theorist and a thinker divorcing truth from morality is refreshingly questionable.--L. M. P. (shrink)

Of Peter Abelard's logical writings, the fruit of thirty-five years of his activity as a teacher and dialectician, there have been to date only four editions worthy of note: that of Cousin in 1836, of Geyer in 1919 and 1936, of Dal Pra in 1954, and lastly the critical reconstruction of Abelard's literal glosses by L. M. Rijk in 1956. With this handsome second edition of minor but relevant glosses of Abelard, Dal Pra aims to fill the gap still existing (...) in the previous collections. His volume includes Abelard's writings found in the Paris BN manuscripts n. 13.368 and 7493. Chronologically the former belongs to the period when Abelard was given the chair of dialectic at the University of Paris in 1114 and the latter to Abelard's more mature period when he began original speculations on the logical status of propositions in 1121. Dal Pra argues at great length that the glosses in the first manuscript are to be read as the best and only introduction to Abelard's own work on dialectic. Hence he suggests against Rijk the title Introductiones Dialecticae rather than Introductiones Parvulorum. He assembles them according to what he believes was Abelard's intellectual development at the time. They are: the glosses to Porphyrius, to Aristotle's Categories, to the De Interpretatione, and to Boethius' De Devisione. [[sic]] The second section of the volume contains the glosses Super Topica where Abelard discusses among other subjects his first position on the problem of universals. Against Geyer who had consigned these works to the literal glosses of Abelard, Dal Pra offers strong evidence for locating them in the bulk of Abelard's De Ingredientibus precisely between the De Interpretatione and the De Syllogismo Hypothetico. The modernity of Abelard's logical theory is well known among contemporary logicians. Dal Pra's finely planned and handsomely executed edition makes an excellent contribution to the history of medieval logic as well as to contemporary logical theories on names and propositions.--L. M. P. (shrink)

This brief monograph consists of three chapters on Nietzsche's sense of tragedy, on perspectivism and on the much debated theory of eternal recurrence. DeFeo believes that the first and last of Nietzsche's works represent the poles between which Nietzsche overthrew metaphysics. In the Birth of Tragedy, the discovery of the existential contradiction of the finite dimension of human existence obtains at the aesthetic level of tragedy. Here the human contradiction is evinced in the wisdom of Dionysius. In The Will to (...) Power, the existential contradiction is understood in the temporal form of an epic: it becomes the ability to overthrow any form of perspectivism. The motive of Nietzsche's philosophy is the search for a novel center of values which, DeFeo believes, Nietzsche finds in the Übermensch. Throughout his short essay, the author constantly cites Husserl, Sartre, and Heidegger. He explicitly interprets Heidegger in the tradition of Nietzsche. Yet it seems rather misleading to assimilate Nietzsche's reduction to Heidegger's existential analysis.--L. M. P. (shrink)

One hundred years separates the birth of T. Campanella from that of G. B. Vico. This collection of essays, published in 1969 by the Archives of Philosophy, is the end result of a congress held in Rome commemorating the birth of both philosophers. Campanella and Vico are celebrated in the same volume on the assumption of ideal affinities besides the accidental circumstances of having been born a century apart. Unfortunately, only one essay is expressly devoted to the analysis of Campanella's (...) and Vico's metaphysics. While the first two papers consider Campanella's medical biography and his epistemology, the last four are dedicated solely to various aspects of Vico's thought. On Iacobelli Isoldi falls the responsibility of justifying the title of the volume. But her attempt to demonstrate a family resemblance between Vico's and Campanella's metaphysics remains farfetched. For Campanella's way of solving the theoretical problem arising from Descartes' dualism issues in inevitable skepticism. Campanella never abandoned the position that the cogito is a vehicle of certainty, but not a criterion of truth. Vico on the other hand, overcomes his initial skepticism by transforming the criterion of truth into a criterion of certainty. In the New Science he demonstrates how man can possess true knowledge of the social and historical sciences. To demonstrate that this symposium had been assembled for reasons other than physical convenience, more papers on possible relations between the Dominican friar of Cosenza and the professor of eloquence of Naples would have been a desideratum.--L. M. P. (shrink)

Objective: To determine whether a moral reasoning exercise can improve response quality to surveys of healthcare priorities Methods: A randomised internet survey focussing on patient age in healthcare allocation was repeated twice. From 2574 internet panel members from the USA and Canada, 2020 (79%) completed the baseline survey and 1247 (62%) completed the follow-up. We elicited respondent preferences for age via five allocation scenarios. In each scenario, a hypothetical health planner made a decision to fund one of two programmes identical (...) except for average patient age (35 vs 65 years). Half of the respondents (intervention group) were randomly assigned to receive an additional moral reasoning exercise. Responses were elicited again 7 weeks later. Numerical scores ranging from –5 (strongest preference for younger patients) to +5 (strongest preference for older patients); 0 indicates no age preference. Response quality was assessed by propensity to choose extreme or neutral values, internal consistency, temporal stability and appeal to prejudicial factors. Results: With the exception of a scenario offering palliative care, respondents preferred offering scarce resources to younger patients in all clinical contexts. This preference for younger patients was weaker in the intervention group. Indicators of response quality favoured the intervention group. Conclusions: Although people generally prefer allocating scarce resources to young patients over older ones, these preferences are significantly reduced when participants are encouraged to reflect carefully on a wide range of moral principles. A moral reasoning exercise is a promising strategy to improve response quality to surveys of healthcare priorities. (shrink)

In many animal species, the early development of the embryo follows a stereotypic pattern of cell cleavage, lineage allocation and generation of tissue asymmetry leading to delineation of the body plan with three primary embryonic axes. The mammalian embryo has been regarded as an exception and primary body axes of the mouse embryo were thought to develop after implantation. However, recent findings have challenged this view. Asymmetry in the fertilised oocyte, as defined by the position of the second polar body (...) and the sperm entry point, can be correlated with the orientation of the animal–vegetal and the embryonic–abembryonic axes in the preimplantation blastocyst. Studies of the pattern of morphogenetic movement of cells and genetic activity in the peri‐implantation embryo suggest that the animal–vegetal axis of the blastocyst might presage the orientation of the anterior–posterior axis of the gastrula. This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis. BioEssays 23:508–517, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The doctrine of double effect (DOE) has its origins in Roman Catholic thought and has been held to have widespread applications in bioethics. Its applications range over issues of maternal-fetal conflict, organ donation and transplant, euthanasia, and resource allocation, among other controversial issues. Recently, Joseph Boyle, the foremost proponent of the DOE over the past few decades, has argued that the DOE is required by the absolutist context of the Catholic tradition, and, further, that anyone who rejects this particular context (...) is not entitled to use the doctrine. In this essay, I will focus exclusively on the intention condition of the DOE and its central distinction, i.e., intention/side effect. I will proceed by considering in turn (1) Boyle's argument that the absolutist moral framework of the Catholic tradition requires the intention/side effect distinction; (2) the ways in which that framework is made vulnerable by this requirement; and (3) just why the DOE should be viable even outside of the Catholic tradition if it turns out that a feature of (l) is correct and the challenges of (2) can be met. (shrink)